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EXPERT ROUNDTABLES

VABYSMO VISIONARIES

EXPERT ROUNDTABLES

Explore key trial results and patient cases with the experts

VABYSMO has allowed my patients the benefit of a dual-pathway medication. Having seen the outcomes in my real-world patients for the past year now, I am increasingly offering VABYSMO as a first-line therapy for my patients.*

Dr. Jordan Graff, MD FACS
Barnet Dulaney Perkins Eye Center

*The contribution of Ang-2 inhibition to the treatment effect and clinical response for nAMD, DME, and RVO has yet to be established.¹ See additional information on the How VABYSMO Works page.

VABYSMO VISIONARIES

Discover why experts are starting with VABYSMO

I have found VABYSMO to be highly effective in treating patients with powerful efficacy and durability.^†‡Its drying capabilities have consistently exceeded my expectations, making it an essential tool in my practice.^§

Dr. Deepak Sambhara, MD
Eye Clinic of Wisconsin

^†VABYSMO met its primary endpoint of non-inferiority vs aflibercept 2 mg in the mean change from baseline in BCVA across nAMD, DME, and RVO.¹ See additional information on the nAMD, DME, and RVO Vision pages.
^‡In nAMD and DME, 1–4 month dosing after 4 or 6 monthly (DME only) loading doses. Monthly dosing for 6 months in RVO.¹ See additional information on the nAMD, DME, and RVO Dosing & Administration pages.
^§Reductions in CST over time were prespecified secondary endpoints. Reductions in CST were observed across all treatment arms throughout the six Phase 3 studies in nAMD, DME, and RVO.¹ See additional information on the nAMD, DME, and RVO Drying pages.

PODCASTS

Hear experts share their real-world experiences with dual-pathway VABYSMO

From Trials to the Clinic: Using a Therapy With a Novel MOA to Treat Patients With DME

Moderator: Dr. John Kitchens 
Speakers: Dr. Maria Berrocal

One of the challenges associated with current anti-VEGF therapies for the management of DME is the need for frequent injections and the potential impact on adherence and vision outcomes. Join Dr. John Kitchens and Dr. Maria Berrocal as they share their experiences treating their DME patients using a therapy with a novel mechanism of action, and how those patient outcomes have influenced their extension decisions and treatment management approaches. This special episode of New Retina Radio, and its content, is supported by Genentech USA, Inc.

A Treatment With a Novel MOA for Patients With nAMD and DME: Perspectives From the Real World

Moderator: Dr. John Kitchens 
Speakers: Dr. David Chin Yee & Dr Margaret Chang

Recent studies have proven the therapeutic viability of a different approach in treating retinal vascular diseases. Join Dr. John Kitchens, Dr. Margaret Chang, and Dr. David Chin Yee as they discuss their clinical experiences using a therapy with a novel mechanism of action in patients with nAMD and DME. And, learn how they approach managing patients with macular edema. This special episode of New Retina Radio, and its content, is supported by Genentech USA, Inc.

A number of my patients who were unable to go beyond Q4W with their current anti-VEGF medication are now able to go up to Q8W, Q12W, or even Q16W with VABYSMO.^¶#

Dr. Charles Eifrig, MD
Retina Associates of Orange County

^¶Dosing may not be generalizable to a broader nAMD or DME population for a variety of reasons.
^#In nAMD and DME, 1–4 month dosing after 4 or 6 monthly (DME only) loading doses. Monthly dosing for 6 months in RVO.¹ See additional information on the nAMD, DME, and RVO Dosing & Administration pages.

CST=central subfield thickness; DME=diabetic macular edema; MOA=mechanism of action; nAMD=neovascular age-related macular degeneration; Q4W=every 4 weeks; Q8W=every 8 weeks; Q12W=every 12 weeks; Q16W=every 16 weeks; RVO=retinal vein occlusion; VEGF=vascular endothelial growth factor.

DRYING

How does drying drive your choice of first-line treatment?

Explore the data

INDICATIONS
VABYSMO (faricimab-svoa) is a vascular endothelial growth factor (VEGF) inhibitor and angiopoietin-2 (Ang-2) inhibitor indicated for the treatment of patients with Neovascular (Wet) Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema (DME), and Macular Edema following Retinal Vein Occlusion (RVO).

IMPORTANT SAFETY INFORMATION

Contraindications
VABYSMO is contraindicated in patients with ocular or periocular infection, in patients with active intraocular inflammation, and in patients with known hypersensitivity to faricimab or any of the excipients in VABYSMO. Hypersensitivity reactions may manifest as rash, pruritus, urticaria, erythema, or severe intraocular inflammation.

Warnings and Precautions
Endophthalmitis and Retinal Detachments
Intravitreal injections have been associated with endophthalmitis and retinal detachments. Proper aseptic injection techniques must always be used when administering VABYSMO. Patients should be instructed to report any symptoms suggestive of endophthalmitis or retinal detachment without delay, to permit prompt and appropriate management.

Increase in Intraocular Pressure
Transient increases in intraocular pressure (IOP) have been seen within 60 minutes of intravitreal injection, including with VABYSMO. IOP and the perfusion of the optic nerve head should be monitored and managed appropriately.

Thromboembolic Events
Although there was a low rate of arterial thromboembolic events (ATEs) observed in the VABYSMO clinical trials, there is a potential risk of ATEs following intravitreal use of VEGF inhibitors. ATEs are defined as nonfatal stroke, nonfatal myocardial infarction, or vascular death (including deaths of unknown cause).

The incidence of reported ATEs in the nAMD studies during the first year was 1% (7 out of 664) in patients treated with VABYSMO compared with 1% (6 out of 662) in patients treated with aflibercept.

The incidence of reported ATEs in the DME studies from baseline to week 100 was 5% (64 out of 1,262) in patients treated with VABYSMO compared with 5% (32 out of 625) in patients treated with aflibercept.

The incidence of reported ATEs in the RVO studies during the first 6 months was 1.1% (7 out of 641) in patients treated with VABYSMO compared with 1.4% (9 out of 635) in patients treated with aflibercept.

Retinal Vasculitis and/or Retinal Vascular Occlusion
Retinal vasculitis and/or retinal vascular occlusion, typically in the presence of intraocular inflammation, have been reported with the use of VABYSMO. Healthcare providers should discontinue treatment with VABYSMO in patients who develop these events. Patients should be instructed to report any change in vision without delay.

Adverse Reactions
The most common adverse reactions (≥5%) reported in patients receiving VABYSMO were cataract (15%) and conjunctival hemorrhage (8%).

Pregnancy, Lactation, Females and Males of Reproductive Potential
Based on the mechanism of action of VEGF and Ang-2 inhibitors, there is a potential risk to female reproductive capacity, and to embryo-fetal development. VABYSMO should not be used during pregnancy unless the potential benefit to the patient outweighs the potential risk to the fetus. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for VABYSMO and any potential adverse effects on the breastfed child from VABYSMO. Females of reproductive potential are advised to use effective contraception prior to the initial dose, during treatment and for at least 3 months following the last dose of VABYSMO.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see additional Important Safety Information in the full VABYSMO Prescribing Information.

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